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MOTS-c
16-amino-acid peptide encoded in the mitochondrial genome.
$49$4.90/mg
- Form: lyophilized (freeze-dried) powder, sealed vial
- Certificate of analysis: batch 026-M83-TSX, HPLC purity 99.02% — view PDF
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For laboratory research use only. Not for human or veterinary use.
Compound identity
| Compound | Formula | Mol. weight | CAS | PubChem |
|---|---|---|---|---|
| MOTS-c | C101H152N28O22S2 | 2174.6 g/mol | 1627580-64-6 | CID 146675088 |
Reference identity data from PubChem where listed. Each batch's purity data is on its certificate of analysis on the lab results page.
Research overview
MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino-acid peptide first described in 2015 1.
Mouse studies have examined its role in metabolic regulation and skeletal muscle, including direct binding to the kinase CK2 12. A 2023 review summarizes the field 3.
References
Where this research was done: 
United States (3), 
China (1), 
Greece (1), 
Italy (1), 
Sweden (1)
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab, 2015. PubMed 25738459
- MOTS-c modulates skeletal muscle function by directly binding and activating CK2. iScience, 2024. PubMed 39559755
- MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Front Endocrinol (Lausanne), 2023. PubMed 36761202
- The Mitochondrial-Derived Peptide MOTS-c May Refine Mortality and Cardiovascular Risk Prediction in Chronic Hemodialysis Patients. Blood Purification, 2024. PubMed 39111290
- Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors. Scientific Reports, 2021. PubMed 34413391
- Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans. Journal of Applied Physiology, 2021. PubMed 34351816
- Effects of Glucagon-Like Peptide-1 Receptor Agonists, Sodium-Glucose Cotransporter-2 Inhibitors, and Their Combination on Neurohumoral and Mitochondrial Activation in Patients With Diabetes. Journal of the American Heart Association, 2025. PubMed 40008510
Storage
Store sealed vials cold, dry and away from light. Lyophilized peptides are typically kept at −20 °C for long-term storage.
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